Intermediates in the Protein Folding Process: A Computational Model
نویسندگان
چکیده
منابع مشابه
Intermediates in the Protein Folding Process: A Computational Model
The paper presents a model for simulating the protein folding process in silico. The two-step model (which consists of the early stage-ES and the late stage-LS) is verified using two proteins, one of which is treated (according to experimental observations) as the early stage and the second as an example of the LS step. The early stage is based solely on backbone structural preferences, while t...
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To determine the pathway by which a protein folds up, it is necessary to characterize the structures of folding intermediates and also to place these intermediates in the correct order on the kinetic pathway of folding. Noncovalent folding reactions are fast: typically they occur in seconds or less for small single-domain proteins. On the other hand, hours are required to obtain detailed struct...
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The folding reactions of some small proteins show clear evidence of a hierarchic process, whereas others, lacking detectable intermediates, do not. Evidence from folding intermediates and transition states suggests that folding begins locally, and that the formation of native secondary structure precedes the formation of tertiary interactions, not the reverse. Some notable examples in the liter...
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Mihai Pop May 28, 1996 Abstract We review several results related to the protein folding problem. We start by analyzing the nature of the interactions among protein atoms and their in uence on folding. We then examine several approaches to solve the folding problem, or restricted versions thereof. We conclude with a survey of results related to the computational complexity of the protein foldin...
متن کاملThe Thermodynamics and Kinetics of Protein Folding: A Lattice Model Analysis of Multiple Pathways with Intermediates
The kinetics and thermodynamics of folding of a representative sequence of a 125-residue protein model subject to Monte Carlo dynamics on a simple cubic lattice were investigated. The diverse trajectories that lead to the native state can be classified into a relatively small number of average pathways: a “fast track” in which the chain forms a stable core that folds directly to the native stat...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2011
ISSN: 1422-0067
DOI: 10.3390/ijms11084850